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National Institute on Dental and Craniofacial Research (NIDCR)

Infectious Diseases and Immunity
A. Develop oral topical formulations with combined microbicidal, analgesic, and anti-inflammatory activities to enhance oral mucosal defenses and prevent and/or control oral infections and lesions in HIV-infected and/or immunosuppressed subjects.
Clinical Research
A. Develop improved methods to detect and predict progression of dental caries, periodontal disease, reversible pulpitis and irreversible pulpitis.
B. Improve or develop new methods to enhance oral and craniofacial surgery. This would include both intraoral and extraoral surgery.
C. Develop improved methods to mechanically repair or treat tooth structure damaged by dental caries or periodontal disease.
Oral, Oropharyngeal and Salivary Gland Cancers
A. Develop regimens for the alleviation of the oral complications of cancer therapy.
B. Develop imaging techniques for the early detection, diagnosis and prognosis of pre-malignant lesions.
Temporomandibular Joint Disorder and Orofacial Pain
A. Discovering and developing novel, pharmacological medications for treating chronic orofacial pain disorders, by leveraging results from ongoing genetic studies of chronic pain conditions
Saliva, Salivary Diagnostics, and Salivary Gland Diseases
A. Development of viral, non-viral and gene therapy-based approaches to address compromised salivary gland function. Development of cell and tissue-based strategies and technologies for restoration of damaged or destroyed salivary gland function.
B. Development of novel compounds or materials that protect and preserve salivary glands from head and neck cancer irradiation therapy.
C. Development of non-invasive methods for the determination of efficacy and safety of artificial saliva, sialogogues, and of their delivery vehicles used in addressing the diminution or lack of saliva (xerostomia) due to Sj?gren?s Syndrome or head and neck cancer irradiation therapy.
D. Development of immunological strategies and immunotherapy-based approaches for addressing xerostomia from Sj?gren?s Syndrome.
Biotechnology, Biomaterials, and Applications for Regeneration and Restoration of Oral, Dental and Craniofacial Tissues
A. Development of methods, materials, and devices for orthodontic, prosthetic, and craniofacial applications including those that can be used for craniofacial bone distraction, craniofacial reconstruction, healing, and scarless repair.
B. Development of imagining diagnostics to accelerate clinical implementation of reliable, reproducible, highly specific and sensitive diagnostic instruments for dental caries, cracked teeth, pulp vitality, bone quality, and periodontal diseases.
Clinical and Behavioral Research
A. Develop and test for safety, efficacy, and/or effectiveness of measures or materials for diagnosing, preventing, or treating oral, dental, and craniofacial conditions and disorders.

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