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National Institute of General Medical Sciences (NIGMS)

Division of Cell Biology and Biophysics
A. Development of instrumentation, devices, and methods for detecting in real time, analyzing, and separating biologically important compounds, macromolecules, and their interactions.
B. Development of new methods and materials directed toward the solution of biological macromolecule structures, including membrane proteins, assemblies and complexes by, but not limited to, x-ray diffraction, electron diffraction, NMR and mass spectroscopy.
C. Imaging probes and sensors, other reagents and methods, instrumentation, software for microscopy, spectroscopy, and single molecule analysis of molecules, cells, tissues, embryos and small model organisms. Technologies for applications of microscopy, spectroscopy and single molecule analysis in basic biomedical research, including but not limited to light, electron, X-ray and scanning probe microscopy and fluorescence, magnetic and electron paramagnetic spectroscopy. NOT included are small animal and preclinical imaging and high throughput platforms for diagnostic and clinical applications.
D. Development of high-throughput and computational methods and strategies to define/characterize the function and interactions of biological macromolecules and cells.
Division of Genetics and Developmental Biology
A. Development of probes for detection of human genetic polymorphisms, including disease genes.
B. Development of valid animal models for genetic diseases and birth defects.
C. Development of tools and technologies to detect and monitor complex human phenotypes or traits.
D. Development or improvement of methods for high throughput detection of epigenomic changes.
E. Development of improved technology, reagents and tools to derive, grow, isolate, differentiate and characterize cells.
Division of Pharmacology, Physiology, and Biological Chemistry
A. Methods for isolation, characterization, and production of natural and bio-engineered products.
B. Development of methodology to improve the efficiency of discovery, development, and production of bio-medically relevant compounds.
C. Isolation, characterization, and development of factors and strategies, methods, or treatments involved in tissue repair, wound healing, sepsis, and traumatic injury, emergency, peri-operative, or critical care conditions, and associated pain management.
D. Research to improve drug design and delivery.
E. Development of technologies, including instrumentation, software, reagents, and methods for proteomics, including but not limited to robotics, sample preparation and pre-fractionation, analytical separations, mass spectrometry, intelligent automated data acquisition, and improved informatics technologies.
F. Development of technologies, including instrumentation, software, reagents, and methods for glycomics, including but not limited to development of: specific glycan structural databases, methodologies for synthesis of robust glycan libraries, glycan labeling reagents and glyco-enzyme inhibitors, and analytical tools for determining carbohydrate structure and biological function.
Division of Biomedical Technology, Bioinformatics, and Computational Biology
A. Development of instrumentation and devices for detection, analysis and separation of biologically important molecules, and for elucidating their interactions both in vitro and intra-cellularly.
B. Development of information and communication technology from computer and other quantitative sciences in support of biomedical or behavioral research, that apply best practices and proven methods for software design, construction and implementation to promote adoption by a broad biomedical research community.

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