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Division of Program Coordination, Planning, and Strategic Initiatives (DPCPSI), Office of Research Infrastructure Programs (ORIP)

RESEARCH AND DEVELOPMENT IN COMPARATIVE MEDICINE
A. Development of new technologies to rapidly phenotype large number of animals.
B. Development of technologies to identify biomarkers for clinical diagnostics in well validated disease models.
C. Development of vaccines and new therapeutic agents to prevent and/or control selected laboratory animal diseases. One high priority need is to develop methods to control and prevent Herpes virus B in nonhuman primates.
D. Design of specialized equipment and caging for laboratory animals to permit optimal environmental control and operational efficiency, including improvements in caging and remote monitoring in animal facilities.
E. Identification, development, and characterization of spontaneous and engineered vertebrate animal models for studies of various human diseases, excluding most random mutagenesis projects performed on rodents.
F. Development and refinement of high throughput technologies and devices for the effective cryopreservation, long-term maintenance, and monitoring of stem cells and laboratory animal embryos, gametes, and their predecessors.
G. Development of improved reagents, techniques, and equipment to perform, analyze, capture and process data gathered in ?omics? studies (genomics, transcriptomics, phenomics, proteomics, glycomics, epigenomics, metabolomics) in normal and disease-condition animal models.
H. Development of biological tools and reagents for reconstruction, remodeling, repair and regeneration of tissues damaged by injury or disease. Development of the technologies and procedures to test efficacy and safety of these experiments in animal models. Approaches to detect and track the implanted cells and tissues in vivo.
I. Development of new technologies in animal/cell models to study the function (activation/silencing) of noncoding DNA or RNA regions in the development of diseases.
J. Development of acellular biomaterials, biosensors and reagents to promote, detect and track reconstruction, remodeling, repair and regeneration of tissues damaged by injury or disease.
Other Research Topic(s) within the Mission of the Office of Research Infrastructure Programs
A. Development of methodologies, diagnostics, technologies, equipment, assay systems and portable devices that can be used in community settings, such as health centers, neighborhood clinics, doctor offices, public schools, libraries, and rural and remote locations to facilitate biomedical and behavioral research;
B. Development of culturally appropriate educational materials for student, teacher and community health literacy and disease prevention/intervention such as: software, videos, printed material to facilitate translation and dissemination of evidence-based health information;
C. Innovative applications of health information technology, including telemedicine/telehealth tools and technologies, to facilitate electronic health information exchange, enable clinical research at the point of care, and improve access to quality health care for hard to reach populations; and
D. Development of Serious science, technology, engineering and mathematics (STEM) Games with a biomedical focus that will complement teacher professional development, improve student achievement, career aspirations and expand community health literacy.

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